๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Prediction of Volume of Distribution Values in Humans for Neutral and Basic Drugs Using Physicochemical Measurements and Plasma Protein Binding Data

โœ Scribed by Lombardo, Franco; Obach, R. Scott; Shalaeva, Marina Y.; Gao, Feng


Book ID
126969639
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
94 KB
Volume
45
Category
Article
ISSN
0022-2623

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


[Methods and Principles in Medicinal Che
โœ Faller, Bernard; Urban, Laszlo ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Wiley ๐ŸŒ German โš– 197 KB

The enormous cost incurred when a candidate drug fails in a clinical trial because of poor pharmacological parameters or severe side effects makes it imperative to screen for "safe" drugs in the very early stages of drug development. Various biochemical and other in vitro assays are thus used in con

Prediction of plasma protein binding dis
โœ Hege Christensen; Mark Baker; Geoffrey T. Tucker; Amin Rostami-Hodjegan ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 231 KB ๐Ÿ‘ 1 views

Although displacement from plasma protein binding (dPB) is usually of little clinical significance, it should be taken into account when interpreting changes in total plasma concentrations of drugs subject to metabolically based drug-drug interactions (mDDI). The aim of this study was to develop an