Estimation of ADME properties in drug di
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Juan A. Castillo-Garit; Yovani Marrero-Ponce; Francisco Torrens; Ramón García-Do
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Article
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2008
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John Wiley and Sons
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English
⚖ 276 KB
The in vitro determination of the permeability through cultured Caco-2 cells is the most often-used in vitro model for drug absorption. In this report, we use the largest data set of measured P(Caco-2), consisting of 157 structurally diverse compounds. Linear discriminant analysis (LDA) was used to