𝔖 Bobbio Scriptorium
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Prediction of type 1 diabetes mellitus—a report on three cases

✍ Scribed by G. J. Bruining; J. L. Molenaar; B. M. Jongh; R. S. R. Aarsen; H. K. A. Visser

Publisher
Springer
Year
1985
Tongue
English
Weight
428 KB
Volume
143
Category
Article
ISSN
0340-6997

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✦ Synopsis

In three children (patients 1, 2 and 3) insulindependency was predicted 28, 32 and 4 months, respectively before the disease became clinically manifest, by the finding of islet cell antibodies at that time.

These retrospective findings support the evidence for a long pre-diabetic phase in childhood diabetes, marked by the presence of islet cell antibodies, as well as the linkage of HLA-antigens to the susceptibility to this disease. The possibility of detecting pre-diabetic states in children before the endogenous insulin secretion decreases to the point of producing clinical symptoms support efforts by basic scientists to develop techniques for immunological intervention early in the course of the disease.

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