Environment-specific amino acid substitu
β
John Overington; Dan Donnelly; Mark S. Johnson; Andrej Ε ali; Tom L. Blundell
π
Article
π
2008
π
Cold Spring Harbor Laboratory Press
π
English
β 913 KB
## Abstract The local environment of an amino acid in a folded protein determines the acceptability of mutations at that position. In order to characterize and quantify these structural constraints, we have made a comparative analysis of families of homologous proteins. Residues in each structure a