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Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables

✍ Scribed by Topham, C. M.; Srinivasan, N.; Blundell, T. L.


Book ID
111904569
Publisher
Oxford University Press
Year
1997
Tongue
English
Weight
649 KB
Volume
10
Category
Article
ISSN
1741-0126

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Environment-specific amino acid substitu
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## Abstract The local environment of an amino acid in a folded protein determines the acceptability of mutations at that position. In order to characterize and quantify these structural constraints, we have made a comparative analysis of families of homologous proteins. Residues in each structure a