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Prediction of the renal clearance of cimetidine using endogenousN-1-methylnicotinamide

โœ Scribed by Amor Maiza; Peter T. Daley-Yates


Book ID
112476346
Publisher
Springer
Year
1991
Tongue
English
Weight
875 KB
Volume
19
Category
Article
ISSN
1573-8744

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Ranitidine renal clearance was investigated in the beagle dog with or without concomitant infusion of cimetidine or probenecid. Ranitidine was excreted mainly by renal tubular secretion. Plasma clearance was reduced by probenecid from 198 9 47 to 119 9 41 mL min -1 (mean9 S.D.); renal clearance was