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Prediction of the Effects of the Val66Met Polymorphism on the Conformational Ensemble of an Intrinsically Disordered Protein, Brain-Derived Neurotrophic Factor

✍ Scribed by Lohia, Ruchi; Salari, Reza; Brannigan, Grace


Book ID
122552512
Publisher
Biophysical Society
Year
2014
Tongue
English
Weight
89 KB
Volume
106
Category
Article
ISSN
0006-3495

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## Abstract A functional polymorphism of the brain‐derived neurotrophic factor (BDNF) gene (Val66Met) has been associated with the risk for schizophrenia and volume differences in the hippocampus. However, little is known about the association between progressive brain volume change in schizophreni