The parameters characterizing tissue distribution refer to the tissue/plasma partition coefficients (Kp), which can be used to derive volume of distribution at steady-state (V(ss)). The effort for predicting drug distribution in human has been further expanded to calculation methods using in vitro-b
Prediction of steady-state volume of distribution of acidic drugs by quantitative structure–pharmacokinetics relationships
✍ Scribed by Zvetanka Zhivkova; Irini Doytchinova
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 309 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0022-3549
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📜 SIMILAR VOLUMES
The steady-state and terminal volumes of distribution, as well as the mean residence time of drug in the body (V ss , V $ , and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile C p (t) following intravenous (i.v. bolus or constant rate infusi
A consistent account of the assumptions of the well-stirred perfusion limited model leads to the equation for the organ tissue that does not coincide with that often presented in books and papers. The difference in pharmacokinetic profiles calculated by the valid and the commonly used equations coul
## Abstract The complete enantioseparations of eight aromatic amino acids and four alkyl esters of 2‐phenylglycine were achieved by chiral capillary electrophoresis employing 20 mM Tris‐citric acid background electrolyte (pH 2.50) containing 5.0 mM of (+)‐18‐crown‐6‐tetracarboxylic acid. The relati