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Prediction of plasma concentration–time curve of orally administered theophylline based on a scintigraphic monitoring of gastrointestinal transit in human volunteers

✍ Scribed by Shunji Haruta; Keiichi Kawai; Ryuichi Nishii; Seishi Jinnouchi; Ken-ichi Ogawara; Kazutaka Higaki; Shozo Tamura; Kazuhiko Arimori; Toshikiro Kimura


Book ID
108454049
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
375 KB
Volume
233
Category
Article
ISSN
0378-5173

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✍ Shunji Haruta; Keiichi Kawai; Seishi Jinnouchi; Ken-ichi Ogawara; Kazutaka Higak 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 282 KB 👁 2 views

The gastrointestinal (GI) transit and absorption of orally administered theophylline, a highly absorbable drug without presystemic elimination, were investigated under fasted and fed conditions using three rats in a crossover study. To evaluate the GI transit rate for each segment in vivo, a noninva