Evaluation of absorption kinetics of ora
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Shunji Haruta; Keiichi Kawai; Seishi Jinnouchi; Ken-ichi Ogawara; Kazutaka Higak
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Article
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2001
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John Wiley and Sons
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English
⚖ 282 KB
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The gastrointestinal (GI) transit and absorption of orally administered theophylline, a highly absorbable drug without presystemic elimination, were investigated under fasted and fed conditions using three rats in a crossover study. To evaluate the GI transit rate for each segment in vivo, a noninva