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Prediction of lung cancer risk in a Chinese population using a multifactorial genetic model

✍ Scribed by Huan Li, Lixin Yang, Xueying Zhao, Jiucun Wang, Ji Qian…

Book ID
120679265
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
200 KB
Volume
13
Category
Article
ISSN
1471-2350

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## Abstract Overexpression of MDM2 may attenuate the P53 stress response pathway through direct blocking of P53 transcriptional activity and mediating P53 degradation. Two promoter polymorphisms (one is a T to G substitution at the intronic P53‐response promoter, and the other is a 40‐bp insertion/