Prediction of the volume of distribution
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W. A. Ritschel; R. D. Johnson; N. N. Vachharajani; A. S. Hussain
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Article
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1992
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John Wiley and Sons
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English
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## Abstract The essential parameter to estimate the first dose size of a drug in man is the volume of distribution. For a drug that has never been used in man before, estimates of the volume of distribution can only be obtained from animals and __in vitro__ data. The purpose of this study was to co