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Prediction of In Vivo Tissue Distribution from In Vitro Data 1. Experiments with Markers of Aqueous Spaces

✍ Scribed by Peter Ballard; David E. Leahy; Malcolm Rowland


Book ID
110251643
Publisher
Springer US
Year
2000
Tongue
English
Weight
36 KB
Volume
17
Category
Article
ISSN
0724-8741

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Prediction of the volume of distribution
✍ W. A. Ritschel; R. D. Johnson; N. N. Vachharajani; A. S. Hussain πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 661 KB

## Abstract The essential parameter to estimate the first dose size of a drug in man is the volume of distribution. For a drug that has never been used in man before, estimates of the volume of distribution can only be obtained from animals and __in vitro__ data. The purpose of this study was to co