✦ LIBER ✦

Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling

✍ Scribed by Miriam Verwei; Johan A. van Burgsteden; Cyrille A.M. Krul; Johannes J.M. van de Sandt; Andreas P. Freidig

Book ID: 119378317
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 254 KB
Volume: 165
Category: Article
ISSN: 0378-4274
DOI: 10.1016/j.toxlet.2006.01.017

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Prediction of in vivo effect levels for

Prediction of in vivo effect levels for reproductive toxicity based on in vitro tests and PBPK modelling

✍ Miriam Verwei; Ine Waalkens-Berendsen; Mariska Tegelenbosch-Schouten; Andreas Fr 📂 Article 📅 2007 🏛 Elsevier Science 🌐 English ⚖ 75 KB

Variability of physiologically based pha

Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE)

✍ Gearhart, J.M.; Mahle, D.A.; Greene, R.J.; Seckel, C.S.; Flemming, C.D.; Fisher, 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 901 KB

Model predicting the teratogenic potenti

Model predicting the teratogenic potential of retinyl palmitate, using a combined in vivo/in vitro approach

✍ Ritchie, H. E.; Webster, W. S.; Eckhoff, C.; Oakes, D. J. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB 👁 2 views

Retinyl palmitate (RP) is a known laboratory animal teratogen inducing abnormalities of the second visceral arch when administered on day 9 of gestation in the rat. However, there are significant problems when attempting to extrapolate this result to the human. A combined in vivo/in vitro model was

Synergistic antitumor effect of TRAIL in

Synergistic antitumor effect of TRAIL in combination with sunitinib in vitro and in vivo

✍ Wanjing Ding; Tianyu Cai; Hong Zhu; Rui Wu; Chongxing Tu; Liuqing Yang; Wei Lu; 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 769 KB

Studies on the toxicity of cyclophospham

Studies on the toxicity of cyclophosphamide in combination with mesna in vitro and in vivo

✍ Millar, Barbara C.; Millar, J.L.; Clutterbuck, R.; Jinks, Sally 📂 Article 📅 1983 🏛 Elsevier Science 🌐 English ⚖ 680 KB

[ACS Symposium Series] Parameters for Pe

[ACS Symposium Series] Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment Volume 1099 || Use of in Vitro Data in PBPK Models: An Example of in Vitro to in Vivo Extrapolation with Carbaryl

✍ Knaak, James B.; Timchalk, Charles; Tornero-Velez, Rogelio 📂 Article 📅 2012 🏛 American Chemical Society ⚖ 895 KB