✦ LIBER ✦

Prediction of in vivo drug–drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

✍ Scribed by Hayley S. Brown; Kiyomi Ito; Aleksandra Galetin; J. Brian Houston

Book ID: 108641430
Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 296 KB
Volume: 60
Category: Article
ISSN: 0306-5251
DOI: 10.1111/j.1365-2125.2005.02483.x

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Database analyses for the prediction of

Database analyses for the prediction of in vivo drug–drug interactions from in vitro data

✍ Kiyomi Ito; Hayley S. Brown; J. Brian Houston 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 337 KB

Simulation and prediction of in vivo dru

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

✍ Rostami-Hodjegan, Amin; Tucker, Geoffrey T. 📂 Article 📅 2007 🏛 Nature Publishing Group 🌐 English ⚖ 798 KB

Quantitative Prediction of In Vivo Drug-

Quantitative Prediction of In Vivo Drug-Drug Interactions from In Vitro Data Based on Physiological Pharmacokinetics: Use of Maximum Unbound Concentration of Inhibitor at the Inlet to the Liver

✍ Shin-ichi Kanamitsu; Kiyomi Ito; Yuichi Sugiyama 📂 Article 📅 2000 🏛 Springer US 🌐 English ⚖ 385 KB

Prediction of plasma protein binding dis

Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug–drug interactions from in vitro data

✍ Hege Christensen; Mark Baker; Geoffrey T. Tucker; Amin Rostami-Hodjegan 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 231 KB 👁 1 views

Although displacement from plasma protein binding (dPB) is usually of little clinical significance, it should be taken into account when interpreting changes in total plasma concentrations of drugs subject to metabolically based drug-drug interactions (mDDI). The aim of this study was to develop an

Identification of human cytochrome P450s

Identification of human cytochrome P450s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data

✍ Xue-Qing Li; Anders Björkman; TommyB. Andersson; LarsL. Gustafsson; CollenM. Mas 📂 Article 📅 2003 🏛 Springer 🌐 English ⚖ 363 KB

Quantitative prediction of in vivo inhib

Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation

✍ Verawan Uchaipichat; Leanne K. Winner; Peter I. Mackenzie; David J. Elliot; J An 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 305 KB