๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: volume of distribution at steady state

โœ Scribed by Toshihiro Wajima; Kazuya Fukumura; Yoshitaka Yano; Takayoshi Oguma


Book ID
111768834
Publisher
Pharmaceutical Press
Year
2003
Tongue
English
Weight
279 KB
Volume
55
Category
Article
ISSN
2042-7158

No coin nor oath required. For personal study only.


๐Ÿ“œ SIMILAR VOLUMES


Prediction of human pharmacokinetics fro
โœ Toshihiro Wajima; Kazuya Fukumura; Yoshitaka Yano; Takayoshi Oguma ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 145 KB

The aim of the study reported here was to develop a regression equation for predicting oral clearance of various kinds of drugs in humans using experimental data from rats and dogs and molecular structural parameters. The data concerning the oral clearance of 87 drugs from rats, dogs, and humans wer

Prediction of human clearance from anima
โœ Toshihiro Wajima; Kazuya Fukumura; Yoshitaka Yano; Takayoshi Oguma ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 146 KB

The aim of the study reported here was to develop a method for predicting human clearance that can be applied to various kinds of drugs using clearance values for rats and dogs and some molecular structural parameters. The clearance data for rats, dogs, and humans of 68 drugs were obtained from lite

On the accuracy of estimation of basic p
โœ Leonid M. Berezhkovskiy ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 339 KB ๐Ÿ‘ 1 views

The steady-state and terminal volumes of distribution, as well as the mean residence time of drug in the body (V ss , V $ , and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile C p (t) following intravenous (i.v. bolus or constant rate infusi