The aim of the study reported here was to develop a regression equation for predicting oral clearance of various kinds of drugs in humans using experimental data from rats and dogs and molecular structural parameters. The data concerning the oral clearance of 87 drugs from rats, dogs, and humans wer
Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: volume of distribution at steady state
โ Scribed by Toshihiro Wajima; Kazuya Fukumura; Yoshitaka Yano; Takayoshi Oguma
- Book ID
- 111768834
- Publisher
- Pharmaceutical Press
- Year
- 2003
- Tongue
- English
- Weight
- 279 KB
- Volume
- 55
- Category
- Article
- ISSN
- 2042-7158
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๐ SIMILAR VOLUMES
The aim of the study reported here was to develop a method for predicting human clearance that can be applied to various kinds of drugs using clearance values for rats and dogs and some molecular structural parameters. The clearance data for rats, dogs, and humans of 68 drugs were obtained from lite
The steady-state and terminal volumes of distribution, as well as the mean residence time of drug in the body (V ss , V $ , and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile C p (t) following intravenous (i.v. bolus or constant rate infusi