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Prediction of human clearance of therapeutic proteins: simple allometric scaling method revisited

โœ Scribed by Weirong Wang; Thomayant Prueksaritanont


Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
127 KB
Volume
31
Category
Article
ISSN
0142-2782

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๐Ÿ“œ SIMILAR VOLUMES


Prediction of human drug clearance from
โœ Kosalaram Goteti; C. Edwin Garner; Iftekhar Mahmood ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 147 KB

The objective of the study was to assess the degree of accuracy in human drug clearance prediction from two species using four different allometric approaches: simple allometry (SA), multiexponential allometry (ME), rule of exponents (ROE), and fixed exponents (FE) as suggested by Tang et al. There

A global examination of allometric scali
โœ Huadong Tang; Michael Mayersohn ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 186 KB

Allometrically scaled data sets (138 compounds) used for predicting human clearance were obtained from the literature. Our analyses of these data have led to four observations. (1) The current data do not provide strong evidence that systemic clearance (CL(s); n = 102) is more predictable than appar

Interspecies scaling of protein drugs: P
โœ Iftekhar Mahmood ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 90 KB

The objective of this study was to evaluate the interspecies scaling for therapeutic protein drugs to predict the systemic clearance in humans from animal data. This study was undertaken to examine whether the rule of exponents of Mahmood and Balian for the prediction of clearance of nonprotein drug