The objective of the study was to assess the degree of accuracy in human drug clearance prediction from two species using four different allometric approaches: simple allometry (SA), multiexponential allometry (ME), rule of exponents (ROE), and fixed exponents (FE) as suggested by Tang et al. There
Prediction of human clearance of therapeutic proteins: simple allometric scaling method revisited
โ Scribed by Weirong Wang; Thomayant Prueksaritanont
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 127 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0142-2782
- DOI
- 10.1002/bdd.708
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Allometrically scaled data sets (138 compounds) used for predicting human clearance were obtained from the literature. Our analyses of these data have led to four observations. (1) The current data do not provide strong evidence that systemic clearance (CL(s); n = 102) is more predictable than appar
The objective of this study was to evaluate the interspecies scaling for therapeutic protein drugs to predict the systemic clearance in humans from animal data. This study was undertaken to examine whether the rule of exponents of Mahmood and Balian for the prediction of clearance of nonprotein drug