Prediction of Hepatic Metabolic Clearance
✍ Scribed by Jochen Zuegge, Gisbert Schneider, Philippe Coassolo, Dr Thierry Lavé
- Book ID
- 119926362
- Publisher
- Springer International Publishing AG
- Year
- 2001
- Tongue
- English
- Weight
- 208 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0312-5963
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It was suggested that in vivo hepatic clearance, CL h , may be predicted rather accurately with the in vitro values of intrinsic clearance, CL int , obtained using the microsomal incubation mix containing diluted plasma, and consequently calculated by the well-stirred model equation. Conceivably the
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