Prediction of drug terminal half-life and terminal volume of distribution after intravenous dosing based on drug clearance, steady-state volume of distribution, and physiological parameters of the body
β Scribed by Berezhkovskiy, Leonid M.
- Book ID
- 118763308
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 230 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
A consistent account of the assumptions of the well-stirred perfusion limited model leads to the equation for the organ tissue that does not coincide with that often presented in books and papers. The difference in pharmacokinetic profiles calculated by the valid and the commonly used equations coul
The steady-state and terminal volumes of distribution, as well as the mean residence time of drug in the body (V ss , V $ , and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile C p (t) following intravenous (i.v. bolus or constant rate infusi