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Prediction of drug-drug interaction from In vitro plasma protein binding and metabolism: A study of tolbutamide-sulfonamide interaction in rats

โœ Scribed by Osamu Sugita; Yasufumi Sawada; Yuichi Sugiyama; Tatsuji Iga; Manabu Hanano


Book ID
115775964
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
662 KB
Volume
30
Category
Article
ISSN
0006-2952

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Prediction of plasma protein binding dis
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Although displacement from plasma protein binding (dPB) is usually of little clinical significance, it should be taken into account when interpreting changes in total plasma concentrations of drugs subject to metabolically based drug-drug interactions (mDDI). The aim of this study was to develop an