Prediction of Clearance, Volume of Distribution and Half-life by Allometric Scaling and by use of Plasma Concentrations Predicted from Pharmacokinetic Constants: a Comparative Study

A comparative study of allometric scalin

A comparative study of allometric scaling with plasma concentrations predicted by species-invariant time methods

✍ Iftekhar Mahmood; Rae Yuan 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 134 KB

The objective of this study is to compare the empirical allometric approaches with species invariant time methods using equivalent time, kallynochron, apolysichron, and dienetichrons. Pharmacokinetic parameters (clearance, volume of distribution, and elimination half-life) of ethosuximide, cyclospor