Prediction of chemical toxicity to aquatic organisms: ECOSAR vs. Microtox� Assay
✍ Scribed by Cash, G. G.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 106 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1053-4725
No coin nor oath required. For personal study only.
✦ Synopsis
This study was designed to compare the toxicities of various chemical explosives and ( ᮋ related compounds to aquatic organisms as predicted by a luminescent bacterium assay Microtox ) assay and by the computer program ECOSAR. Toxicities were rated ''very toxic,'' ''toxic,'' or ''less toxic'' using the same criteria as the published bacterium assay. The two methods agree for most of the 24 compounds studied, and the disagreements are about equally divided as to which method predicts the greater toxicity. Experimental toxicity data were available for 12 of the 24 compounds. With these data, ECOSAR made eight predictions that coincided with the experimental toxicity class, while the luminescent bacterium assay predicted seven. For 17 of 21 experimental LC values, ECOSAR 50 predicted log LC within one log unit.