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Prediction of Anti and gauche vicinal proton-proton coupling constants for hexapyranose rings using a generalized karplus equation

✍ Scribed by C. A. G. Haasnoot; F. A. A. M. De Leeuw; C. Altona


Publisher
Wiley (John Wiley & Sons)
Year
2010
Weight
409 KB
Volume
89
Category
Article
ISSN
0037-9646

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✦ Synopsis


Abstract

A new coupling constant ‐ torsion angle relation for the three‐bond ^1^H‐^1^H spin‐spin coupling constants is utilized to explore the effect of endocyclic and exocyclic oxygen atoms on Jae, Jee and Jaa in hexapyranoid systems. Attention is paid to common stereochemical surroundings rather than to individual compounds. It is shown that a simplified model for the flattened six‐membered ring, incorporating a constant geometry irrespective of the location of the coupled protons, correctly reproduces all the main trends observed.