Predicting Transcription Factor Complexes: A Novel Approach to Data Integration in Systems Biology

✍ Scribed by Thorsten Will (auth.)

• Publisher: Springer Spektrum
• Year: 2015
• Tongue: English
• Leaves: 155
• Series: BestMasters
• Edition: 1
• Category: Library

✦ Synopsis

In his master thesis Thorsten Will proposes the substantial information content of protein complexes involving transcription factors in the context of gene regulatory networks, designs the first computational approaches to predict such complexes as well as their regulatory function and verifies the practicability using data of the well-studied yeast S.cereviseae. The novel insights offer extensive capabilities towards a better understanding of the combinatorial control driving transcriptional regulation.

✦ Table of Contents

Front Matter....Pages I-XIX
Introduction....Pages 1-23
Related work....Pages 25-43
Materials and Methods....Pages 45-87
Results and Discussion....Pages 89-110
Conclusion and Outlook....Pages 111-112
Back Matter....Pages 113-142

✦ Subjects

Bioinformatics; Computer Appl. in Life Sciences; Mathematical and Computational Biology