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Predicting the Functional, Molecular, and Phenotypic Consequences of Amino Acid Substitutions using Hidden Markov Models

โœ Scribed by Shihab, Hashem A.; Gough, Julian; Cooper, David N.; Stenson, Peter D.; Barker, Gary L. A.; Edwards, Keith J.; Day, Ian N. M.; Gaunt, Tom R.


Book ID
118759315
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
339 KB
Volume
34
Category
Article
ISSN
1059-7794

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Signal peptides are N-terminal sequences that mediate the targeting and translocation of secreted or cell-surface proteins to the endoplasmic reticulum (ER) membrane. Because of the variability among signal peptides, traditional methods for predicting the effects of an amino acid substitution based