✦ LIBER ✦
Predicting partition coefficients for isomeric diastereoisomers of some tripeptide analogs
✍ Scribed by Nicholas Bodor; Ming-Ju Huang
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 384 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0192-8651
No coin nor oath required. For personal study only.
✦ Synopsis
The octanol-water partition coefficients (Log P) of tripeptide diastereoisomers have been calculated by our recently developed method for predicting Log P from the results of AM1 semiempirical calculations. This method can distinguish different diastereoisomers. The differences arise from variations in molecular conformation, which lead to significant differences in the dipole moment and ovality of the different diastereoisomers.