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Predicting Enantioselectivity: Computation as an Efficient “Experimental” Tool for Probing Enantioselectivity

✍ Scribed by Andrea Ragusa; Joseph M. Hayes; Mark E. Light; Jeremy D. Kilburn


Book ID
102178561
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
123 KB
Volume
2006
Category
Article
ISSN
1434-193X

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## Abstract **Mild mannered!** A highly diastereo‐ and enantioselective Mannich‐type reaction of glycine Schiff base **1** has been developed by using the __N,N′__‐dioxide **L**‐Cu^II^ complex as a catalyst. Various optically active __anti‐__α,β‐diamino acid esters were obtained in good yields with