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Predicting Cancer Risk from Vinyl Chloride Exposure with a Physiologically Based Pharmacokinetic Model

โœ Scribed by Richard H. Reitz; Michael L. Gargas; Melvin E. Andersen; W.M. Provan; Trevor L. Green


Book ID
112266069
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
210 KB
Volume
137
Category
Article
ISSN
0041-008X

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Physiologically based pharmacokinetic (PBPK) models were developed for design and optimization of liposome therapy for treatment of overdoses of tricyclic antidepressants and local anesthetics. In vitro drug-binding data for pegylated, anionic liposomes and published mechanistic equations for partit