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Predicted and trifluoroethanol-induced α-helicity of polypeptides

✍ Scribed by Mary Koeppe Luidens; James Figge; Kimberly Breese; Sandor Vajda

Publisher
Wiley (John Wiley & Sons)
Year
1998
Tongue
English
Weight
801 KB
Volume
39
Category
Article
ISSN
0006-3525

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✦ Synopsis

The a-helix stabilizing solvent 2,2,2-trifluoroethanol (TFE) is.fiequently used as a medium for determining the average a-helicity of polypeptides by CD spectroscopy. CD spectra measured in solutions containing 10. 15, 20, SO, and 90% (vol/vol) TFE are presented,for S peptides that were selected to demonstrate possible variations in the effect of TFE concentration on the secondary structure. The analysis is extended to 6 further peptides whose CD spectra as measured in TFE are documented in the literature. The observed a-helicity at a high TFE concentration is compared with the a-helicity determined by a structure prediction method that combines conformational filtering [

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