We have shown that linear estimates of rates of disease progression (LEP), derived from isometric myometry [grip or foot dorsiflexion (FD) strength] and forced vital capacity (FVC%), are clinically and statistically significant predictors of survival of patients with amyotrophic lateral sclerosis (A
β¦ LIBER β¦
Predictability of disease progression in amyotrophic lateral sclerosis
β Scribed by Adam Czaplinski; Albert A. Yen; Ericka P. Simpson; Stanley H. Appel
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 161 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0148-639X
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It is now possible to slow the disease progression of amyotrophic lateral sclerosis (ALS), but documented improvement in the quality of life of ALS patients has been difficult to quantitate. Putative mechanisms involved in motor neuron degeneration in ALS include oxidative damage, mitochondrial dysf