𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Prediagnostic levels of C-peptide, IGF-I, IGFBP -1, -2 and -3 and risk of endometrial cancer

✍ Scribed by Annekatrin Lukanova; Anne Zeleniuch-Jacquotte; Eva Lundin; Andrea Micheli; Alan A. Arslan; Sabina Rinaldi; Paola Muti; Per Lenner; Karen L. Koenig; Carine Biessy; Vittorio Krogh; Elio Riboli; Roy E. Shore; Par Stattin; Franco Berrino; Göran Hallmans; Paolo Toniolo; Rudolf Kaaks

Publisher
John Wiley and Sons
Year
2003
Tongue
French
Weight
122 KB
Volume
108
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Conditions related to chronic hyperinsulinemia, such as obesity, noninsulin dependent diabetes mellitus and polycystic ovary syndrome, are associated with an increased risk of endometrial cancer. Elevated plasma IGF‐I and decreased levels of IGF‐binding proteins have been shown to be associated with increased risk of several cancer types that are frequent in affluent societies. We investigated for the first time in a prospective study the association of pre‐diagnostic blood concentrations of C‐peptide (a marker of pancreatic insulin production), IGF‐I, IGFBP‐1, ‐2 and ‐3 with endometrial cancer risk. A case‐control study was nested within 3 cohorts in New York (USA), Umeå (Sweden) and Milan (Italy). It included 166 women with primary invasive endometrial cancer and 315 matched controls, of which 44 case and 78 control subjects were premenopausal at recruitment. Endometrial cancer risk increased with increasing levels of C‐peptide (p~trend~ = 0.0002), up to an odds ratio (OR) of 4.76 [95% confidence interval (CI) = 1.91–11.8] for the highest quintile. This association remained after adjustment for BMI and other confounders [OR for the top quintile = 4.40 (1.65–11.7)]. IGFBP‐1 levels were inversely related to endometrial cancer [p~trend~ = 0.002; OR in the upper quintile = 0.30 (0.15–0.62)], but the association was weakened and lost statistical significance after adjustment for confounders [p~trend~ = 0.06; OR in the upper quintile = 0.49 (0.22–1.07)]. Risk was unrelated to levels of IGF‐I, IGFBP‐2 and IGFBP‐3. Chronic hyperinsulinemia, as reflected by increased circulating C‐peptide, is associated with increased endometrial cancer risk. Decrease in the prevalence of chronic hyperinsulinemia, through changes in lifestyle or medication, is expected to prevent endometrial cancer. © 2003 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Serum levels of C-peptide, IGFBP-1 and I
Serum levels of C-peptide, IGFBP-1 and IGFBP-2 and endometrial cancer risk; Results from the European prospective investigation into cancer and nutrition
✍ Anne E. Cust; Naomi E. Allen; Sabina Rinaldi; Laure Dossus; Christine Friedenrei 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 203 KB 👁 2 views

## Abstract We conducted a case‐control study nested within the European Prospective Investigation into Cancer and Nutrition, to examine the associations between prediagnostic serum concentrations of C‐peptide, insulin‐like growth factor binding protein (IGFBP)‐1 and IGFBP‐2, and endometrial cancer

Serum concentrations of IGF-I, IGFBP-3 a
Serum concentrations of IGF-I, IGFBP-3 and c-peptide and risk of hyperplasia and cancer of the breast in postmenopausal women
✍ Catherine Schairer; Deirdre Hill; Susan R. Sturgeon; Thomas Fears; Michael Polla 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 88 KB 👁 2 views

## Abstract Experimental evidence suggests that insulin and insulin‐related growth factors may play a role in breast pathology through their mitogenic and anti‐apoptotic effects on breast cells. Our objective was to assess the relationship between serum concentrations of insulin‐like growth factor‐

Serum C-peptide, IGFBP-1 and IGFBP-2 and
Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and Nutrition
✍ Mazda Jenab; Elio Riboli; Rebecca J. Cleveland; Teresa Norat; Sabina Rinaldi; Al 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 114 KB 👁 2 views

## Abstract Western style diets and lifestyles are associated with increasing rates of obesity, diabetes and insulin resistance. Higher circulating insulin levels may modulate cell proliferation and apoptosis either directly or indirectly by increasing the bioactivity of IGF‐I and decreasing the bi

Genetic variation and circulating levels
Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease
✍ Xuefen Su; Graham A. Colditz; Walter C. Willett; Laura C. Collins; Stuart J. Sch 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 157 KB 👁 2 views

## Abstract Insulin‐like growth factor‐I (IGF‐I) and its major binding protein IGFBP‐3 have been implicated in breast carcinogenesis. We examined the associations between genetic variants and circulating levels of IGF‐I and IGFBP‐3 with proliferative benign breast disease (BBD), a marker of increas

Serum levels of IGF-I, IGFBP-3 and color
Serum levels of IGF-I, IGFBP-3 and colorectal cancer risk: results from the EPIC cohort, plus a meta-analysis of prospective studies
✍ Sabina Rinaldi; Rebecca Cleveland; Teresa Norat; Carine Biessy; Sabine Rohrmann; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 220 KB 👁 2 views

## Abstract Several prospective studies have shown a moderate positive association between increasing circulating insulin‐like growth factor‐I (IGF‐I) levels and colorectal cancer risk. However, the associations were often statistically nonsignificant, and the relationship of cancer risk with IGF‐I

IGF-1 and IGFBP-3: Risk of prostate canc
IGF-1 and IGFBP-3: Risk of prostate cancer among men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
✍ Jocelyn M. Weiss; Wen-Yi Huang; Sabina Rinaldi; Thomas R. Fears; Nilanjan Chatte 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 91 KB 👁 1 views

## Abstract IGF‐1 and IGFBP‐3 may influence risk of prostate cancer through their roles in cellular growth, metabolism and apoptosis, however, epidemiologic results have been inconsistent. The role of obesity in prostate cancer risk is not clearly understood, but hyperinsulinemia‐related increases