✦ LIBER ✦
Precursor directed biosynthesis of novel 6-deoxyerythronolide B analogs containing non-natural oxygen substituents and reactive functionalities
✍ Scribed by Daniel Hunziker; Nicholas Wu; Kenji Kenoshita; David E. Cane; Chaitan Khosla
- Book ID
- 104260504
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 258 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Feeding of synthetic precursors to a blocked mutant of 6-deoxyerythronoltde B synthase (DEBS) [1] led to production of novel 6-deoxyerythronolide B analogs in vivo containing additional non-natural oxygen substituents as well as additional reactive groups.