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Preclinical Toxicity Evaluation of Tepoxalin, a Dual Inhibitor of Cyclooxygenase and 5-Lipoxygenase, in Sprague–Dawley Rats and Beagle Dogs

✍ Scribed by E.V. Knight; J.P. Kimball; C.M. Keenan; I.L. Smith; F.A. Wong; D.S. Barrett; A.M. Dempster; W.G. Lieuallen; D. Panigrahi; W.J. Powers; R.J. Szot

Book ID
115608683
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
142 KB
Volume
33
Category
Article
ISSN
0272-0590

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📜 SIMILAR VOLUMES

Antinociceptive effects of a novel dual
Antinociceptive effects of a novel dual cyclooxygenase/5-lipoxygenase inhibitor (tepoxalin) and its primary (carboxylic acid) metabolite (RWJ 20142) in acute tests in mice and rats
✍ Robert B. Raffa; Charlene D. Connelly; Rebecca P. Martinez; James J. Schupsky; D 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 875 KB

## Abstract Tepoxalin is a novel dual inhibitor of cyclooxygenase (CO) and lipoxygenase (LO) pathways of arachidonic acid metabolism with a relative lack of gastrointestinal side effects within its preclinical therapeutic dose range. The present study investigated the antinociceptive action of tepo