muM17 is an anti-mouse CD11a monoclonal antibody (mAb) developed as a surrogate molecule for assessing potential reproductive toxicities of efalizumab, an anti-human CD11a mAb approved for treatment of chronic moderate to severe plaque psoriasis. This article shows the use of a mechanism-based PK/PD
โฆ LIBER โฆ
Preclinical PK/PD modeling and human efficacious dose projection for a glucokinase activator in the treatment of diabetes
โ Scribed by Zager, Michael G.; Kozminski, Kirk; Pascual, Bernadette; Ogilvie, Kathleen M.; Sun, Shaoxian
- Book ID
- 121536589
- Publisher
- Springer
- Year
- 2014
- Tongue
- English
- Weight
- 371 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1573-8744
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## Abstract ## Background. Radiofrequency ablation (RFA) is a minimally invasive tumor destruction technique and can provide the antigen source initiating tumor immunity. However, induced immune response is weak and requires additional immunotherapy for optimized RFA treatment against cancer. ##