Hyperthermia
β Nathan A. Busch, Duane F. Bruley, Haim I. Bicher (auth.), Haim I. Bicher, Duane
π Library
π
1982
π Springer US
π English
β¦ LIBER β¦
π
Preclinical Hyperthermia
β Scribed by R. H. Burdon (auth.), Dr. Wolfgang Hinkelbein, Dipl. Phys. Gregor Bruggmoser, Prof. Dr. Rupert Engelhardt, Prof. Dr. Dr. Michael Wannenmacher (eds.)
- Publisher
- Springer-Verlag Berlin Heidelberg
- Year
- 1988
- Tongue
- English
- Leaves
- 270
- Series
- Recent Results in Cancer Research 109
- Edition
- 1
- Category
- Library
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β¦ Synopsis
Physicians and biologists here present their experimental work in the field of hyperthermia, paying particular regard to its relevance in clinical situations. Principles of heat action and combined treatment modalities are explicated. The main topics discussed are the effects of such treatment on normal tissues, animal tumors, malignant cell lines and human tumors.
β¦ Table of Contents
Front Matter....Pages I-XI
Hyperthermic Toxicity and the Modulation of Heat Damage to Cell Protein Synthesis in HeLa Cells....Pages 1-8
Membranes as Targets for Hyperthermic Cell Killing....Pages 9-21
Sulfhydryl Compounds as Thermosensitizers....Pages 22-27
Therapeutic Benefit from Combined Heat and Radiation....Pages 28-34
Correlation Between Polymerase Γ Activity and Thermal Radiosensitization in Chinese Hamster Ovary Cells....Pages 35-41
The Problem of Defining Thermal Dose....Pages 42-49
Effect of Hyperthermia on Human Natural Killer Cells....Pages 50-56
Effect of Hyperthermia at 40.5Β° C and Cytostatic Drugs on Human Bone Marrow Progenitor Cells....Pages 57-63
Combined Heat and X-Ray Toxicities in Intestine and Skin....Pages 64-70
Toxic Effects of Irradiation or Doxorubicin in Combination with Moderate Whole-Body Hyperthermia on Bone Marrow in Rats....Pages 71-82
Cardiotoxicity of Moderate Whole-Body Hyperthermia, Doxorubicin, and Combined Treatment in Rats....Pages 83-88
Effects of Hyperthermic Treatments on Malignant Cells and Animal Tumors: Introductory Remarks....Pages 89-95
Hyperthermia and Microcirculatory Effects of Heat in Animal Tumors....Pages 96-108
Importance of the Glutathione Level and the Activity of the Pentose Phosphate Pathway in Cellular Heat Sensitivity....Pages 109-125
Potentiation of Hyperthermia by Lanthanum....Pages 126-135
Interactions of Hyperthermia with Hypoxic Cell Sensitisers....Pages 136-148
Thermal Enhancement of the Cell Killing Effect of X-Irradiation in Mammalian Cells in Vitro and in a Transplantable Mouse Tumor: Influence of pH, Thermotolerance, Hypoxia, or Misonidazole....Pages 149-160
Thermal Enhancement of Drug Cytotoxicity in Vivo and in Vitro....Pages 161-169
Preclinical Hyperthermia in Human Tumors: Introductory Remarks....Pages 170-172
Microcirculatory and pH Alterations in Isotransplanted Rat and Xenotransplanted Human Tumors Associated with Hyperthermia....Pages 173-182
Effects of Heat Treatment in Vitro and in Vivo on Human Melanoma Xenografts....Pages 183-197
Intrinsic Thermosensitivity of Various Human Tumors....Pages 198-202
Importance of Thermotolerance for Radiothermotherapy as Assessed Using Two Human Melanoma Cell Lines....Pages 203-213
In Vitro Thermochemotherapy in Ovarian Cancer....Pages 214-223
Effect of Hyperthermia at 40.5Β° C and Chemotherapy on Various Human Tumors in Vitro....Pages 224-238
Predictive Assays for Tumor Response to Single and Multiple Fractions of Hyperthermia....Pages 239-249
Predicting the Sensitivity of Human Cancers to Combined Chemotherapy and Hyperthermia....Pages 250-257
Back Matter....Pages 258-263
β¦ Subjects
Oncology
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