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Preclinical evaluation of dasatinib in melanoma cell lines

โœ Scribed by A.J. Eustace; J. Crown; M. Clynes; N. O'Donovan

Book ID
119598831
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
88 KB
Volume
6
Category
Article
ISSN
1359-6349

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โœ Alex J. Eustace; Paul Dowling; Michael Henry; Padraig Doolan; Paula Meleady; Mar ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Elsevier ๐ŸŒ English โš– 973 KB

Current therapeutic regimes for metastatic melanoma have failed to provide robust clinical responses. Dasatinib has shown anti-proliferative and anti-invasive effects in vitro; however, not all melanoma cells tested were sensitive to dasatinib. We used 2D-DIGE analysis of phospho-enriched fractions