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Preclinical Evaluation of Anti-HIV-1 Polybiguanide Vaginal Microbicides in a Murine Model of Toxicity and Inflammation

✍ Scribed by Tina Kish-Catalone, Mohamed E Labib, Robert F Rando, Brian Wigdahl…


Book ID
120692950
Publisher
BioMed Central
Year
2005
Tongue
English
Weight
70 KB
Volume
2
Category
Article
ISSN
1742-4690

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## Abstract Cognitive, behavioral, and motor impairments, during progressive human immunodeficiency virus type 1 (HIV‐1) infection, are linked to activation of brain mononuclear phagocytes (MP; perivascular macrophages and microglia). Activated MPs effect a giant cell encephalitis and neuroinflamma