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Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor

✍ Scribed by Pancras C. Wong; Donald J. P. Pinto; Donglu Zhang

Book ID
106544412
Publisher
Springer US
Year
2011
Tongue
English
Weight
554 KB
Volume
31
Category
Article
ISSN
0929-5305

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## Abstract Apixaban is a potent inhibitor of blood coagulation Factor Xa in the late stages of development. [^14^C]apixaban was synthesized with the 14C label in the two different lactam ring systems within the molecule for various __in vitro__ and __in vivo__ metabolism studies. A nine‐step synth