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Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties

✍ Scribed by Tietje, Karin R. ;Anderson, David J. ;Bitner, R. Scott ;Blomme, Eric A. ;Brackemeyer, Paul J. ;Briggs, Clark A. ;Browman, Kaitlin E. ;Bury, Dagmar ;Curzon, Peter ;Drescher, Karla U. ;Frost, Jennifer M. ;Fryer, Ryan M. ;Fox, Gerard B. ;Gronlien, Jens Halvard ;Håkerud, Monika ;Gubbins, Earl J. ;Halm, Sabine ;Harris, Richard ;Helfrich, Rosalind J. ;Kohlhaas, Kathy L. ;Law, Devalina ;Malysz, John ;Marsh, Kennan C. ;Martin, Ruth L. ;Meyer, Michael D. ;Molesky, Angela L. ;Nikkel, Arthur L. ;Otte, Stephani ;Pan, Liping ;Puttfarcken, Pamela S. ;Radek, Richard J. ;Robb, Holly M. ;Spies, Eva ;Thorin-Hagene, Kirsten ;Waring, Jeffrey F. ;Ween, Hilde ;Xu, Hongyu ;Gopalakrishnan, Murali ;Bunnelle, William H.


Book ID
109105740
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
413 KB
Volume
14
Category
Article
ISSN
1080-563X

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## Abstract Nicotine activates specific receptors that are cation‐permeable ionic channels located in the central and autonomous nervous systems, as well as at the neuromuscular junction. Administration of nicotine to animals and humans has been shown to enhance cognitive processes. However, side e