Precision Estimation in Zelen's Single-Consent Design

✍ Scribed by J. P. Matts; R. B. McHugh

• Book ID: 101713850
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 284 KB
• Volume: 35
• Category: Article
• ISSN: 0323-3847
• DOI: 10.1002/bimj.4710350107

✦ Synopsis

The precision of a treatment contrast, as conventionally estimated in Zelen's Single-Consent Design, is shown under randomization theory to be positively biased. The magnitude of this bias is demonstrated and a new statistic is derived which is a consistent estimator of the precision. Confidence interval estimation for the treatment contrast is also presented.