Precise localization on chromosome 12 of the ATF-1 gene by fluorescence in situ hybridization

✍ Scribed by C. Desmaze; J. Zucman; O. Delattre; T. Melot; G. Thomas; A. Aurias

• Publisher: Springer
• Year: 1994
• Tongue: English
• Weight: 197 KB
• Volume: 93
• Category: Article
• ISSN: 0340-6717
• DOI: 10.1007/bf00210613

✦ Synopsis

The ATF-1 gene encodes for a transcription factor normally regulated by cAMP (Hai et al. 1989, Yoshimura et al. 1990). Recently, it has been shown to be involved in the recurrent t(12;22) translocation observed in soft tissue malignant melanoma, in a fusion gene with the EWS gene (Zucman et al. 1993). We report here on its precise localization on chromosome 12 by fluorescence in situ hybridization.