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Precipitation of phenyl and phenoxypenicillin from solutions using ammonium sulfate

✍ Scribed by JoséM. Luengo

Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
414 KB
Volume
149
Category
Article
ISSN
0003-2697

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✦ Synopsis

An easy, rapid, and available method for separating 6-aminopenicillanic acid (6-APA), benzylpenicillin (penicillin G), and other related molecules from aqueous solutions or complex industrial broths is described. A high concentration of ammonium sulphate induces partially or totally the precipitation of the penicillin present in the solutions, while 6-APA, phenylacetic, and phenoxyacetic acid always remain in the supernatant. The filtration through No. 4 Pyrex glass-fiber filter or Whatman 3MM paper permits the separation of the compounds present in the supernatant from the other ones precipitated. The precipitated product was identified, in all cases, as ammonium penicillin. This method is described here for the first time.

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