Precancerous and cancerous breast lesions during lifetime and at autopsy. A study of 83 women
✍ Scribed by Maja Nielsen; Jørn Jensen; Johan Andersen
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 391 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
✦ Synopsis
Among 83 consecutive, unselected female autopsy cases, 6 had been treated for invasive breast carcinoma (IBC) during lifetime. At autopsy, of these six women, two had IBC in the contralateral breast, and another two had in situ carcinoma. Among the 77 women without previous clinical breast cancer, one case of IBC and 14 cases of in situ carcinoma were found at autopsy. Thus, the total Occurrence of primary malignant breast lesion was as high as 25.4%. Assuming that all IBCs evolve from in situ forms and that in situ carcinomas do not undergo total regression, our results seem to indicate that about one third of all in situ carcinomas develop into IBC.
Cancer 54:612-615, 1984.
HE FREQUENCY of breast carcinoma, either invasive T or in situ, has not yet been established in the general population.
Reviews of hospital autopsies have partly addressed this problem, 1-4 but these investigations have not been rigorously conducted.
Population-based screening studies of breast carcinoma, notably in Sweden, have produced more reliable estimates of breast malignancy, especially that of invasive carcin ~m a . ~-'
In a Danish county with a known stable population and a very high autopsy rate of 52% of all deaths, we studied the frequency of breast carcinoma and atypical lesions in 83 unselected women. The protocol was designed to accurately determine the lifetime occurrence of these lesions with specific regard to their clinical or subclinical nature.