Pre-Type 1 (insulin-dependent) diabetes: common endocrinological course despite immunological and immunogenetic heterogeneity

✍ Scribed by S. Srikanta; O. P. Ganda; R. A. Jackson; S. J. Brink; E. Fleischnick; E. Yunis; C. Alper; J. S. Soeldner; G. S. Eisenbarth

• Publisher: Springer
• Year: 1984
• Tongue: English
• Weight: 294 KB
• Volume: 27
• Category: Article
• ISSN: 0012-186X
• DOI: 10.1007/bf00275674

✦ Synopsis

In an ongoing prospective study 32 individuals have been evaluated for insulin secretory dynamics, islet cell antibodies and HLA antigens, during the preclinical phase of Type 1 diabetes mellitus. Twenty-four out of the 32 subjects were islet cell antibody-positive. To date, 14 subjects (10 islet cell antibody-positive, four islet cell antibody-negative) have progressed to develop overt diabetes. Several patterns of HLA-DR expression were noted (DR3/DR4, DR3/DR3, DR3/x, DR3/DR1, DR4/x, DR4/DR7, DR5/DR7, DR1/DR7 and DR1/DR2). Irrespective of differences in islet cell antibody status or HLA-DR alleles, pre-diabetic individuals exhibited a similar slow course of progressive beta-cell dysfunction.