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Pre-TCR Signaling and Inactivation of p53 Induces Crucial Cell Survival Pathways in Pre-T Cells

✍ Scribed by Mariëlle C Haks; Paul Krimpenfort; Jeroen H.N van den Brakel; Ada M Kruisbeek


Book ID
117722513
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
275 KB
Volume
11
Category
Article
ISSN
1074-7613

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## Abstract A p53 C‐terminal peptide (aa 361–382, p53p), fused at its C‐terminus to the minimal carrier peptide of __antennapedia__ (17 aa, Ant; p53p‐Ant), induced rapid apoptosis in human cancer cells, __via__ activation of the Fas pathway. We examined p53p‐Ant mechanism of action, toxicity in var