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Pre-radiation chemotherapy for newly diagnosed childhood brain tumors—A modified phase 11 trial

Book ID
122983347
Publisher
Elsevier Science
Year
1982
Weight
175 KB
Volume
18
Category
Article
ISSN
0277-5379

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## Abstract ## BACKGROUND Temozolomide (TMZ) and 1, 3‐bis (2‐chloroethyl)‐1‐nitrosourea (BCNU) are reported to be active agents in anaplastic glioma (AG). TMZ has also been shown to deplete alkyltransferase, a DNA repair enzyme that contributes to nitrosourea resistance. The objective of the curre