Pre-messenger RNA processing and its regulation: a genomic perspective

Overlapping transcripts, double-stranded

Overlapping transcripts, double-stranded RNA and antisense regulation: A genomic perspective

✍ S. H. Munroe; J. Zhu 📂 Article 📅 2006 🏛 Springer 🌐 English ⚖ 431 KB

Missense mutations and single nucleotide

Missense mutations and single nucleotide polymorphisms in ABCB11 impair bile salt export pump processing and function or disrupt pre-messenger RNA splicing

✍ Jane A. Byrne; Sandra S. Strautnieks; Gudrun Ihrke; Franco Pagani; A.S. Knisely; 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 818 KB

The gene encoding the human bile salt export pump (BSEP), ABCB11, is mutated in several forms of intrahepatic cholestasis. Here we classified the majority (63) of known ABCB11 missense mutations and 21 single-nucleotide polymorphisms (SNPs) to determine whether they caused abnormal ABCB11 pre-messen