Pre-irradiation chemotherapy for infants and children with medulloblastoma: a preliminary report
โ Scribed by Kretschmar, Cynthia S.; Tarbell, Nancy J.; Kupsky, William; Lavally, Beverly L.; Loeffler, Jay S.; Wolfe, Lawrence; Strand, Roy; Scott, R. Michael; Sallan, Stephen E.
- Book ID
- 120404130
- Publisher
- American Association of Neurological Surgeons
- Year
- 1989
- Tongue
- English
- Weight
- 712 KB
- Volume
- 71
- Category
- Article
- ISSN
- 1933-0693
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The results of treatment of infants with medulloblastoma using surgery and chemotherapy, without the use of radiation therapy, are reported. Both survival and outcome, in terms of growth, neurologic deficit, and intelligence are compared with the same parameters in children treated conventionally. A
The prognosis of recurrent medulloblastoma remains extremely poor. Combination chemotherapy with cisplatin (CDDP) and etoposide (VP-16) was given to five children with early recurrent medulloblastoma. As a rule, CDDP 20 mg/m2 per day and VP-16 60 mg/m2 per day were administered intravenously for 5 d