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Pre- and postnatal diagnosis of peroxisomal disorders using stable-isotope dilution gas chromatography - mass spectrometry

✍ Scribed by N. M. Verhoeven; W. Kulik; C. M. M. van den Heuvel; C. Jakobs

Book ID: 104899990
Publisher: Springer
Year: 1995
Tongue: English
Weight: 929 KB
Volume: 18
Category: Article
ISSN: 0141-8955
DOI: 10.1007/bf00711428

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## Abstract D‐Serine is a co‐agonist of the __N__‐methyl‐D‐aspartate receptor in glutamate neurotransmission and has been proposed as a potential therapeutic agent for schizophrenia. However, D‐serine also acts as a nephrotoxic substance in rats at high doses. To investigate the pharmacokinetics an