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Pre- and postmortem diffusion coefficients in rat neural and muscle tissues

✍ Scribed by J. R. Macfall; J. H. Maki; G. A. Johnson; L. W. Hedlund; G. P. Cofer

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
616 KB
Volume
20
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Pulsed gradient diffusion‐weighted spin‐echo images (7 to 11 gradient strengths) were obtained in a coronal slice through the midbrain for five normal adult white rats before and after sacrifice in a 2‐T CSI system with air temperature control. The pulse sequence was cardiac gated and respiratory synchronized in order to minimize motion artifacts (Tr > 2 s, Te ‐ 30 ms). Diffusion coefficients reflecting several tissue compartments (D^*^) in brain and muscle were calculated and referenced to simultaneously imaged tubes of water. In the living animals, brain cortical matter had a value of D^*^ = (0.82 ± 0.02) × 10^3^ mm^2^/s, deeper brain regions had a value of D^*^ = (0.73 ± 0.02) × 10^‐3^ mm^2^/s, and the muscle had a value of D^*^ = (1.4 ± 0.1) × 10^3^ mm^2^/s. Postmortem the values in brain dropped by approximately 30%, while remaining constant in muscle. Signal intensity in the spin‐echo images for muscle tissue rose by 50% over a 1‐ to 2‐h interval after sacrifice while that of brain tissue remained relatively stable. © 1991 Academic Press, Inc.

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