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Pravastatin reduces lung metastasis of rat hepatocellular carcinoma via a coordinated decrease of MMP expression and activity

✍ Scribed by Danièle Taras; Jean-Frédéric Blanc; Anne Rullier; Nathalie Dugot-Senant; Ingrid Laurendeau; Michel Vidaud; Jean Rosenbaum

Book ID
116651154
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
451 KB
Volume
46
Category
Article
ISSN
0168-8278

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Activation of the precursor of gelatinas
Activation of the precursor of gelatinase A/72 kda type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasis
✍ Masato Tokuraku; Hiroshi Sato; Sinya Murakami; Yasunori Okada; Yoh Watanabe; Mot 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 French ⚖ 871 KB

We have identified a novel membrane-type matrix metalloproteinase (MT-MMP) expressed on the cell surface and inducing activation of pro-gelatinase A in vitro. In this study, we further examined the possibility that MT-MMP is the activator of pro-gelatinase A in tumors as well as in vitro. Expression