Pramipexole in patients with early Parkinson's disease (PROUD): a randomised delayed-start trial
β Scribed by Schapira, Anthony HV; McDermott, Michael P; Barone, Paolo; Comella, Cynthia L; Albrecht, Stefan; Hsu, Helen H; Massey, Daniel H; Mizuno, Yoshikuni; Poewe, Werner; Rascol, Olivier; Marek, Kenneth
- Book ID
- 120391230
- Publisher
- The Lancet
- Year
- 2013
- Tongue
- English
- Weight
- 235 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1474-4465
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## Abstract Perhaps the most important unmet need in Parkinson's disease (PD) is the ability to slow or prevent progression of the neurodegeneration that underlies the motor and nonmotor features of this disorder. Pramipexole, a dopamine agonist used for the symptomatic treatment of PD, has demonst
## Abstract To compare the safety and efficacy of low dosages of pramipexole given twice daily (bid) in early Parkinson's disease (PD) with those of a standard 3 times daily (tid) regimen in a randomized, doubleβblind, placebo controlled trial involving 311 early PD patients not receiving dopaminer