Practice and Principles of Pharmacodynamic Determination of HISS-Dependent and HISS-Independent Insulin Action: Methods to Quantitate Mechanisms of Insulin Resistance

Practice and principles of pharmacodynam

Practice and principles of pharmacodynamic determination of HISS-dependent and HISS-independent insulin action: Methods to quantitate mechanisms of insulin resistance

✍ W. Wayne Lautt 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 142 KB

## Abstract Injection of insulin causes release of HISS (hepatic insulin sensitizing substance) from the liver in the fed state. HISS action accounts for 50–60% of the glucose disposal produced by a wide range of insulin doses (5–100 mU/kg). Although the chemical nature of HISS is unknown, precludi